UDP-glucose 6-dehydrogenase

UDP-glucose 6-dehydrogenase
Identifiers
EC number 1.1.1.22
CAS number 9028-26-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an UDP-glucose 6-dehydrogenase (EC 1.1.1.22) is an enzyme that catalyzes the chemical reaction

UDP-glucose + 2 NAD+ + H2O \rightleftharpoons UDP-glucuronate + 2 NADH + 2 H+

The 3 substrates of this enzyme are UDP-glucose, NAD+, and H2O, whereas its 3 products are UDP-glucuronate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is UDP-glucose:NAD+ 6-oxidoreductase. Other names in common use include UDP-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, UDPG dehydrogenase, UDPG:NAD oxidoreductase, UDP-alpha-D-glucose:NAD oxidoreductase, UDP-glucose:NAD+ oxidoreductase, uridine diphosphate glucose dehydrogenase, UDP-D-glucose dehydrogenase, and uridine diphosphate D-glucose dehydrogenase. This enzyme participates in 4 metabolic pathways: pentose and glucuronate interconversions, ascorbate and aldarate metabolism, starch and sucrose metabolism, and nucleotide sugars metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1DLI, 1DLJ, 2O3J, 2Q3E, and 2QG4.

References